ABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Tietze's Syndrome/microbiology , Chest Pain/microbiology , Spondylitis/microbiology , Coronavirus Infections/complications , Candidiasis/microbiology , Risk Factors , Candidiasis/drug therapy , Adrenal Cortex Hormones/therapeutic use , Azithromycin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Ceftriaxone/therapeutic use , Antibodies, Monoclonal, Humanized/therapeutic use , Coronavirus Infections/therapySubject(s)
Leukoencephalopathy, Progressive Multifocal , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Bendamustine Hydrochloride/adverse effects , Brain , Humans , Leukoencephalopathy, Progressive Multifocal/chemically induced , Leukoencephalopathy, Progressive Multifocal/diagnosis , RituximabABSTRACT
Castleman disease (CD) represents a heterogeneous group of lymphoproliferative disorders that share well-defined histopathological features. An observational study of patients with CD was conducted. A total of 53 patients had CD: 20 had the unicentric form (UCD) and 33 the multicentric (MCD) variant; 10 of the latter cases were infected with human herpesvirus-8 (HHV-8) and 23 were idiopathic (iMCD). Median age differed between UCD and iMCD (30 vs. 49 years, p = .004). Males were completely predominant in HHV-8-associated MCD (100%), and females were more frequent in UCD (75 vs. 48%, p = .06). Relapses were more frequent in iMCD (57 vs. 10% UCD, p = .002), and mortality was significantly higher in iMCD and the HHV-8-associated form with respect to UCD. We conclude that UCD is a benign disorder of younger ages and female predominance, while iMCD represents a different entity with more disease relapses and higher mortality.
Subject(s)
Castleman Disease/mortality , Castleman Disease/pathology , Herpesviridae Infections/complications , Neoplasm Recurrence, Local/mortality , Neoplasm Recurrence, Local/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Castleman Disease/virology , Female , Follow-Up Studies , Herpesviridae Infections/virology , Herpesvirus 8, Human/isolation & purification , Humans , Male , Middle Aged , Neoplasm Recurrence, Local/virology , Prognosis , Retrospective Studies , Spain , Survival Rate , Tertiary Care Centers , Young AdultSubject(s)
Amino Acyl-tRNA Synthetases/immunology , Azathioprine/administration & dosage , Calcinosis , Lung Diseases, Interstitial , Myositis , Paraspinal Muscles , Prednisone/administration & dosage , Tomography, X-Ray Computed/methods , Autoantibodies/blood , Calcinosis/diagnostic imaging , Calcinosis/etiology , Female , Humans , Immunosuppressive Agents/administration & dosage , Lung Diseases, Interstitial/diagnostic imaging , Lung Diseases, Interstitial/etiology , Lung Diseases, Interstitial/therapy , Middle Aged , Myositis/diagnosis , Myositis/immunology , Myositis/physiopathology , Myositis/therapy , Paraspinal Muscles/diagnostic imaging , Paraspinal Muscles/pathologySubject(s)
Granuloma, Respiratory Tract/diagnosis , Head and Neck Neoplasms/diagnosis , Lung Neoplasms/diagnosis , Lung/pathology , Neoplasms, Multiple Primary/diagnosis , Pulmonary Aspergillosis/diagnosis , Aged , Biopsy , Cigarette Smoking , Diagnosis, Differential , Facial Pain , Humans , Lung/diagnostic imaging , Male , Positron Emission Tomography Computed Tomography , TrismusABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Cheilitis/complications , Cheilitis/drug therapy , Edema/complications , Lip , Lip/pathology , Glucocorticoids/administration & dosage , Dapsone/administration & dosage , Radiography, Thoracic/methods , Melkersson-Rosenthal Syndrome/complications , Melkersson-Rosenthal Syndrome/diagnosis , Diagnosis, DifferentialABSTRACT
From a clinical point of view, the most common presentations of cutaneous metastatic disease are papules and nodules. However, a wide morphological spectrum of lesions has been described, including erythematous patches or plaques, inflammatory erysipelas-like lesions, diffuse sclerodermiform lesions with induration of the skin, telangiectatic papulovesicles, purpuric plaques mimicking vasculitis, and alopecia areata like scalp lesions. The so-called zosteriform pattern has been described to be in few cases and to the best of our knowledge has never been described associated with a metastasis of a nasopharyngeal carcinoma. This case highlights the relevance of including cutaneous metastases in the differential diagnosis of patients with nonhealing herpes zoster-like lesions, especially in those with underlying neoplasm recently diagnosed.
